Robuvit oak wood extract has been shown to increase overall energy and to reduce fatigue. Ellagitannins, prominent constituents of Robuvit, are metabolized to the bioactive polyphenols urolithins, which are responsible for an elevated mitophagy, the replacement of dysfunctional mitochondria by newer, fully performant ones. It has been shown that the urolithin levels and even the number of urolithin producers increase after Robuvit supplementation. The expression of the mitochondrial enzyme NADH-dehydrogenase was shown to be enhanced after Robuvit supplementation, leading to a more efficient generation of ATP, the principal molecule for storing and transferring energy in cells. Furthermore, Robuvit supplementation leads to improved translation of ribosomal proteins, the cell machinery of crucial importance for producing new proteins. In addition, by stimulating protein synthesis, growth and differentiation of skeletal muscle are facilitated and the muscular mass increases. Finally, Robuvit significantly de-creases plasma oxidative stress due to its high antioxidant capacity. Indeed, Robuvit efficacy has been confirmed in a series of clinical studies, including generating energy and reducing fatigue in healthy volunteers, in chronic fatigue syndrome, PTSD, and burn-out patients. It also contributes to improving recovery from flu, mononucleosis, postsurgery, heart failure, and liver and kidney insufficiency. Robuvit im-proves sports performance increases general vigour and ameliorates erectile function. The combination of these versatile effects of French oak wood extract Robuvit is a natural pre-requisite for greater endurance, recovery, and performance.